The Favorskii Rearrangement: Synthetic Applications

Author(s): D. Guijarro, M. Yus.

Journal Name: Current Organic Chemistry

Volume 9 , Issue 17 , 2005

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This review deals with the applications of the Favorskii rearrangement in synthetic Organic Chemistry, paying especial attention to the literature appeared after 1980. The mentioned rearrangement plays a key role in many total synthesis due to the fact that important modifications in the structure of the substrate occur during the process. Skeletal rearrangements in acyclic systems, leading to highly branched carboxylic acids and its derivatives, as well as structural changes in cyclic substrates, which result in ring contraction processes, are described. Some examples of Favorskii rearrangements in biosynthetic pathways are also presented.

Keywords: skeletal rearrangement, Deprotonation, cyclopropanone, organic synthesis, Imine Derivatives, Favorskii-Like Processes, Homo-Favorskii Reactions

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Article Details

Year: 2005
Page: [1713 - 1735]
Pages: 23
DOI: 10.2174/138527205774610912
Price: $58

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