Coil column countercurrent chromatography (CC-CCC) has been intensively used for the separation of natural products. Most of these separations have been successfully performed on a laboratory scale. However, scaling-up of this technique for industrial separations is still a challenge. In the present paper scale-up of coil column countercurrent chromatographs with three types of column rotation including high-speed planetary motion around its horizontal axis, cross-axis medium-speed planetary motion and slow rotation around its horizontal axis are reviewed. Up to now, the column capacities of high-speed countercurrent chromatographs, cross-axis countercurrent chromatographs and slow rotary countercurrent chromatographs reach 4.6, 2.5 and 40 liters, respectively. An evaluation scaling-up each type of CCCCC is made.
Keywords: coil column countercurrent chromatography, high-speed countercurrent chromatography, cross axis countercurrent chromatography, slow rotary countercurrent chromatography, scale-up, review, countercurrent chromatography
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