Advances in Chromatographic Analyses of Fluoroquinolones in Pharmaceuticals and Biological Samples - A Review Article

Author(s): Victoria F. Samanidou, Eleni A. Christodoulou, Ioannis N. Papadoyannis

Journal Name: Current Pharmaceutical Analysis

Volume 1 , Issue 3 , 2005

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Fluoroquinolones constitute a member of quinolone antibiotics, an expanding group of synthetic antibiotics, which are effective towards pathogens resistant to other antibacterials. They are broadly used for the treatment of several infections, both in human and veterinary medicine, due to their favourable kinetics and broad antibacterial activity. Herein recent advances in chromatographic methods for determination of fluoroquinolones and their metabolites are reviewed, focusing on sample pretreatment, chromatographic conditions, detection techniques, method validation and application to real samples. Results of published methods are comparatively presented and criticized.

Keywords: fluoroquinolones, metabolites, chromatographic analyses, sample preparation, drugs, pharmaceuticals, biological samples

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Article Details

Year: 2005
Page: [283 - 308]
Pages: 26
DOI: 10.2174/157341205774597922
Price: $65

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