Parallel, Solution Phase Synthesis of Dihydropyridine Miticides Via a Versatile Multicomponent Reaction

Author(s): K. Cottrell, C. W. Holyoke, M. Kline, K. C. Lee, M. R. Nassirpour, R. J. Pasteris, S. Shah

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 8 , Issue 7 , 2005

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A novel class of highly active dihydropyridine miticides was prepared using a multicomponent reaction process. The initial lead was rapidly optimized using solution phase parallel synthesis techniques and a positional scanning approach. Detailed structure-activity relationships were developed for the amino and carbonyl components of the molecule and used to select the best candidates for broad field testing. The chemistry, biology and toxicology of these compounds will be presented along with numerous structural variants of the reaction products.

Keywords: dihydropyridine, dihydropyrimidine, miticide, multicomponent reaction, parallel synthesis, 1,3-dinucleophile, 1,3 dielectrophile

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Article Details

Year: 2005
Page: [617 - 622]
Pages: 6
DOI: 10.2174/138620705774575337
Price: $65

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