Cerebrovascular Damage as a Cause for Alzheimers Disease

Author(s): C. Humpel, J. Marksteiner

Journal Name: Current Neurovascular Research

Volume 2 , Issue 4 , 2005

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Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.

Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade

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Article Details

Year: 2005
Page: [341 - 347]
Pages: 7
DOI: 10.2174/156720205774322610
Price: $65

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