Adipokines: Therapeutic Targets for Metabolic Syndrome

Author(s): Kunihisa Kobayashi, Toyoshi Inoguchi

Journal Name: Current Drug Targets

Volume 6 , Issue 4 , 2005

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For a long time it has been known that obesity (adiposity) is linked to insulin resistance. Recently, many investigators have reported that adipocytes secrete a variety of bioactive molecules, termed adipokines (adipocytokines), including TNFα, IL-6, leptin, adiponectin, resistin and so on. These adipokines play pivotal roles in energy homeostasis by affecting insulin sensitivity, glucose and lipid metabolisms, food intake, the coagulation system and inflammation. This review provides a summary of these adipose tissue-secreting biomolecules and discusses their feasibilities as drug targets for the treatment of metabolic syndrome.

Keywords: cardiovascular disease, atherosclerosis, adipose tissues, tumor necrosis factor, plasminogen activator, interleukin, resistin, lipoprotein, leptin, visfatin

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Article Details

Year: 2005
Page: [525 - 529]
Pages: 5
DOI: 10.2174/1389450054021972
Price: $65

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