The Novartis Compound Archive - From Concept to Reality

Author(s): U. Schopfer, C. Engeloch, J. Stanek, M. Girod, A. Schuffenhauer, E. Jacoby, P. Acklin

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 8 , Issue 6 , 2005

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As HTS technologies come of age, pharmaceutical companies are focusing increasingly on the quality of their screening collections. Storage conditions and their influence on compound stability and solubility are debated intensely. At Novartis, a strategy was developed that is different to most other companies: (1) compounds unsuitable for storage in solution are excluded by computational methods; (2) compounds are stored at 4 C/20% relative humidity in a DMSO/water mixture to avoid freeze-thaw cycles and water uptake and to allow rapid plate replication; (3) resolubilisation of compounds at regular intervals.

Keywords: Compound management, storage conditions, automated weighing, automated solution production, lifecycle management, solution archive

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Article Details

Year: 2005
Page: [513 - 519]
Pages: 7
DOI: 10.2174/1386207054867328
Price: $65

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PDF: 15