Non-Receptor Tyrosine Kinase Inhibitors in Lung Cancer

Author(s): Olwen Hahn, Ravi Salgia

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 7 , Issue 6 , 2007

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Lung cancer is a leading cause of cancer death. Systemic therapies with cytotoxic chemotherapies remain ineffective. Current research efforts in lung cancer have focused on developing novel agents to target cellular pathways that are altered in lung cancer. Protein tyrosine kinases are a family of oncogenes that regulate important cellular processes such as differentiation, proliferation, cell cycle, motility, and apoptosis. In this article, we review non receptor tyrosine kinases ’ role in lung cancer and the development of agents that target these proteins.

Keywords: Lung cancer, non receptor tyrosine kinase inhibitors, novel targets

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Article Details

Year: 2007
Page: [633 - 642]
Pages: 10
DOI: 10.2174/187152007784111322
Price: $65

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