Polymeric Liquid Membrane Electrodes Incorporated with Undecylcalix[4]-Resorcinarene for Screening of Neutral Forms of Diaminobenzene Isomers

Author(s): Katarzyna Kurzatkowska, Hanna Radecka, Wim Dehaen, Michal Wasowicz, Izabela Grzybowska, Jerzy Radecki

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 10 , Issue 7 , 2007

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Abstract:

The PVC supported liquid membrane electrodes incorporated with undecylcalix[4]resorcinarene (UDC[4]Rene) generates a cationic potentiometric response after stimulation by neutral (unprotonated) form of diaminobenzene isomers. The potentiometric signals were generated upon the formation of supramolecular complex between the UDC[4]Rene (host) and diaminobenzene (guest) at the organic-aqueous interface. In this paper for the first time we report the generation of cationic potential signal by electrode incorporated with host molecule possessing oxygen as a heteroatom, after stimulation with neutral guest containing nitrogen in its structure We also broaden the family of receptor molecules, which are able to generate charge separation at the organic/aqueous interface after interaction with uncharged molecules. The results obtained confirm the possibility of applying this potentiometric method for the screening of diaminobenzene isomers identified recently as allergens and endocrine disrupting chemicals.

Keywords: Lipophilic undecylcalix[4]resorcinarenes, diaminobenzene isomers, uncharged molecules, potentiometric responses, amino-calix[4]resorcinarenes

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2007
Page: [604 - 610]
Pages: 7
DOI: 10.2174/138620707782152344
Price: $65

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