Preclinical Testing of Drug-Induced Proarrhythmia: Value of Transgenic Models

Author(s): L. Fabritz, G. Breithardt, P. Kirchhof

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 5 , Issue 4 , 2007

Become EABM
Become Reviewer
Call for Editor


Drug-induced proarrhythmia is a serious medical problem that causes relevant morbidity and mortality. It is also a relevant problem for the development of novel pharmacological compounds. Therefore, there is a need for sensitive, specific and high-throughput preclinical tests to detect a risk for drug-induced proarrhythmia early in the development of new drugs. The review focuses on the potential role of transgenic models with altered repolarisation but without overt structural heart disease for drug-induced proarrhythmia screening. Today, selected murine models with alterations in K+, Na+ channels and ankyrin are available. In the future, transgenic rabbit and Zebra fish models may also be used.

Keywords: Drug-induced proarrhythmia, repolarisation, long QT syndrome, action potential prolongation, torsades de pointes, transgenic model, experimental model, ion channels

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Page: [289 - 294]
Pages: 6
DOI: 10.2174/187152507782109881
Price: $65

Article Metrics

PDF: 6