The Role of Adipokines in Hypertension and Cardiovascular Disease

Author(s): Andrew M. Wilson, Marno C. Ryan

Journal Name: Current Hypertension Reviews

Volume 3 , Issue 3 , 2007

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The prevalence of overweight (currently defined as body mass index (BMI) > 25 kg/m2) and obesity (BMI > 30 kg/m2) is rapidly increasing and has been associated with increased morbidity and mortality. Obesity is associated strongly with insulin resistance and type 2 diabetes, which are major risk factors for hypertension and cardiovascular disease. Recent evidence has emerged that adipocytes function as highly active endocrine cells and secrete a wide range of inflammatory and vaso-active agents. These include leptin and adiponectin which appear to display a range of effects on the cardiovascular system, particularly in vitro. A better understanding of the roles for these and other adiopcyte derived agents in cardiovascular disease pathogenesis may lead to the development of better prevention strategies and novel therapies.

Keywords: Obesity, cardiovascular disease, atherosclerosis, diabetes, hypertension, inflammation

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Article Details

Year: 2007
Page: [208 - 215]
Pages: 8
DOI: 10.2174/157340207781386738
Price: $65

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