Efficacy of the Newest COX-2 Selective Inhibitors in Rheumatic Disease

Author(s): Herbert S.B. Baraf

Journal Name: Current Pharmaceutical Design

Volume 13 , Issue 22 , 2007

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Non-steroidal antiinflammatory drugs (NSAIDs) are standard treatment for the pain and inflammation associated with arthritis. Traditional NSAIDs and cyclooxygenase-2 (COX-2) selective inhibitors exhibit comparable efficacy, with different safety profiles. Traditional NSAIDs are associated with an increased risk of serious gastrointestinal (GI) adverse events versus COX-2 selective inhibitors, and chronic use frequently necessitates adjunctive therapy with gastroprotective agents. COX-2 selective inhibitors are often used in preference to avoid these GI adverse events. Recent studies have raised the concern that COX-2 selective inhibitors and traditional NSAIDs appear to be associated with a higher incidence of thrombotic cardiovascular events versus placebo. The key in prescribing these agents is for the physician to take a proactive approach to patient management and evaluation of GI and cardiovascular risk factors. This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.

Keywords: Etoricoxib, lumiracoxib, COX-2 selective inhibitors, rheumatic disease

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Article Details

Year: 2007
Page: [2228 - 2236]
Pages: 9
DOI: 10.2174/138161207781368819
Price: $65

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PDF: 11