Abstract
Extensive epidemiological and experimental evidence suggests the nutritional environment in which a developing conceptus is exposed is a major factor determining later cardiovascular disease. In this review a consideration of the extent to which altered maternal/fetal nutritional environments may predispose toward later anomalies in blood pressure control and hypertension will be undertaken. In particular, a focus will be on potentially novel mechanistic pathways through which early-mid gestational undernutrition may impact upon fetal/adult adipocyte, renal and brain function, that act to increase the risk of later hypertension developing. Within the review we shall also present an opinion on the differing animal models that are currently employed to address developmental programming and introduce a conceptual framework that synthesises current available evidence.
Keywords: Maternal Nutrition, Angiotensin II, Blood Pressure, Hypertension
Current Drug Targets
Title: Fetal Mechanisms That Lead to Later Hypertension
Volume: 8 Issue: 8
Author(s): D.S. Gardner, R.C. Bell and M.E. Symonds
Affiliation:
Keywords: Maternal Nutrition, Angiotensin II, Blood Pressure, Hypertension
Abstract: Extensive epidemiological and experimental evidence suggests the nutritional environment in which a developing conceptus is exposed is a major factor determining later cardiovascular disease. In this review a consideration of the extent to which altered maternal/fetal nutritional environments may predispose toward later anomalies in blood pressure control and hypertension will be undertaken. In particular, a focus will be on potentially novel mechanistic pathways through which early-mid gestational undernutrition may impact upon fetal/adult adipocyte, renal and brain function, that act to increase the risk of later hypertension developing. Within the review we shall also present an opinion on the differing animal models that are currently employed to address developmental programming and introduce a conceptual framework that synthesises current available evidence.
Export Options
About this article
Cite this article as:
D.S. Gardner , R.C. Bell and M.E. Symonds , Fetal Mechanisms That Lead to Later Hypertension, Current Drug Targets 2007; 8 (8) . https://dx.doi.org/10.2174/138945007781386901
DOI https://dx.doi.org/10.2174/138945007781386901 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Progress and Issues of the Genome-Wide Association Study for Hypertension
Current Medicinal Chemistry Bronchoscopic Appearance of Tracheal Adenoid Cystic Carcinoma
Current Respiratory Medicine Reviews An update on the Management and Treatment of Deep Vein Thrombosis
Cardiovascular & Hematological Agents in Medicinal Chemistry Free Fatty Acids: Circulating Contributors of Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Rationale of Hyperbaric Oxygenation in Cerebral Vascular Insult
Current Vascular Pharmacology Targeting Mitochondria for Cardiac Protection
Current Drug Targets Variation of Antioxidant Capacity in Different Layers of Onion (Allium cepa L.) At Two Different Stages of Maturation
Current Nutrition & Food Science Relationships of Beta2- and Beta3--Adrenoceptor Polymorphisms with Obesity, Hypertension and Metabolic Syndrome
Current Hypertension Reviews Future Therapeutic Strategies in Inflammatory Cardiomyopathy: Insights from the Experimental Autoimmune Myocarditis Model
Cardiovascular & Hematological Disorders-Drug Targets Coronary Atherosclerotic Disease Burden: An Emerging Endpoint in Progression / Regression Studies Using Intravascular Ultrasound
Current Drug Targets - Cardiovascular & Hematological Disorders Non-Invasive Markers of Liver Fibrosis in HCV Mono-Infected and in HIV/HCV Co-Infected Subjects
Medicinal Chemistry Novel Tyrosine Kinase Inhibitors in the Treatment of Cancer
Current Drug Targets Patent Selections
Recent Patents on Cardiovascular Drug Discovery The Cardiac Antihypertrophic Effects of Cyclic GMP-Generating Agents: An Experimental Framework for Novel Treatments of Left Ventricular Remodeling
Vascular Disease Prevention (Discontinued) Editorial from Guest Editor (Thematic Issue: Connective Tissue Disease-Associated Interstitial Lung Disease)
Current Respiratory Medicine Reviews Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches
Current Medicinal Chemistry Metabolism and Pharmacological Mechanisms of Active Ingredients in <i>Erigeron breviscapus</i>
Current Drug Metabolism Retracted: Potential Health Benefits of Broccoli- A Chemico-Biological Overview
Mini-Reviews in Medicinal Chemistry Cardioprotection Against Ischemia/Reperfusion Injury and Chromogranin ADerived Peptides
Current Medicinal Chemistry Cardiovascular Risk Factors: Does Sex Matter?
Current Vascular Pharmacology