ISSN (Print): 1567-2018
ISSN (Online): 1875-5704
Volume 18, 10 Issues, 2021
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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704
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Special Issue Submission
"For many drugs, delivery is as big a challenge as development. Current Drug Delivery provides essential information for all drug scientists."
Jhon de Jersey
The Univ. of Queensland, Australia
Bioactive molecules based nano-formulations for therapy and Drug development
Guest Editor(s): Dr. Meiwan Chen, Dr. Liangzhu Feng, Dr. Xingjie Liang
Tentative Publication Date: December, 2020
Submit Abstract via Email
Drug Delivery Australia
Guest Editor(s): Mariusz Skwarczynski, Ben Boyd
I would like to thank the entire editing team of the Current Drug Delivery for their commitment to resolve all issues regarding the publication of my article. All sectors work in consonance and are quite agile.
I believe that my work is of interest both in the pharmaceutical industry and in the biotechnology industry, since once the bioavailability of the active substance is guaranteed at its site of action, the better is the result for the patient. And so it is in the interest of the whole chain of health goods production, to encourage them to study this issue of biopharmaceutical stability in depth.
At the moment I am working with ophthalmic release systems, which is still in progress. I look forward to future contributions to your journal.
Aline Gravinez Perissinato (LACFAR, Institute of Chemistry, Federal University of Alfenas, Alfenas, Brazil.)
Has contributed: Simple Strategy to Protect Lactase Activity in Solid Formulation.
44 Abstract Ahead of Print are available electronically
79 Articles Ahead of Print are available electronically
Micro and nanoencapsulation are commonly used techniques to reduce the cost of production, enhance the stability of compounds,
modulate their release properties, or enhance their therapeutic activity. Particularly in the medical field, microencapsulation
and nanoencapsulation had a great impact on enhancing the therapeutic outcome of medications, since they enhance their
solubilization, and confer a controlled release nature for these drugs. Recently, several researchers have reported notable advancements
in this regard, and therefore in this full thematic issue of the Current Drug Delivery journal, the impact of drug encapsulation
on the therapeutic outcome of several diseases has been discussed from several perspectives.
The thematic issue starts with a review article by D’Souza and Shegokar, in which they highlighted the importance of the lipidic
system nanostructured lipid carrier in drug delivery, and the role of the liquid lipid component . This was followed by a
review article by Hashimi et al., who emphasized the importance of polymers, either natural or synthetic, in creating micro and
nanoparticles for the treatment of diabetes . Mittal et al., discussed another important topic in their review article: how novel
delivery systems can have a positive role in the treatment of COVID-19 . Another review article written by Feng et al., described
how metal-organic frameworks can be useful as controlled stimuli-responsive drug delivery systems .
The thematic issue also included some research studies highlighting the role of drug encapsulation in medical applications.
For example, Razak et al., described how eugenol in addition to glucose could be used in a delivery system for cancer treatment
, Wu et al., reported how salvianolic acid B could be delivered in mesoporous bioactive glass scaffolds for bone regeneration
, and Kaddouri et al., reported the synthesis of new compounds which can be explored for their antioxidant potential with
cyclodextrin delivery systems . In addition, Yazici et al., reported how carvacrol codrugs could be potentially beneficial
against glioblastoma . Furthermore, Liang et al., described how polylactic, glycolic acid can be used to induce the slow release
of mometasone furoate for the treatment of knee arthritis . Finally, Jain et al., reported the preparation and characterization
of starch nanoparticles conjugated with mannose for targeting liver cancer .
The progress in the field of nanomaterials has led to the development of numerous innovative strategies for effective detection
and treatment of several diseases by workers, scientists and industry .
There are many types of applications found in nanomaterials owing to their physical, mechanical, electrical, magnetic,
chemical and biological properties . However, the use of nanomaterials in the pharmaceutical field, especially in drug delivery
systems, is more interesting than other application areas. An ideal nanomaterial-based system should have properties,
including: (i) a controlled and sustained release profile to maintain the therapeutic concentration of an active substance for a
prolonged period of time, (ii) specific targeting of drugs to improve the pharmacokinetics by controlling the drug delivery in
the desired site and (iii) minimizing or eliminating unwanted side effects .
Moreover, nanostructures such as carbon nanotubes, graphene, quantum dots, metal nanoparticles and polymers are generally
chemically active and their size can be controlled. The use of these nanomaterials is quite common while developing
analysis methods suitable for new technology. Especially, nanomaterials play an important role in increasing sensitivity and
obtaining reliable answers in the pharmaceutical industry, electronics, medicine, food and environmental analysis. They can
be used as labeling, increasing surface area for targets, immobilization process in analytical assays .
This thematic issue of the Current Drug Delivery is focused on the current trends in nanomaterials for both drug delivery
and analysis of drugs. The review articles describe the role of nanomaterials in the treatment of lung cancer (Gencer et al.,),
delivery and assay of anti-migraine drugs (Esim et al.,), electrochemical sensors for the determination of drugs of abuse
(Amiri et al.,) and lipid-coating of nanomaterials for effective cancer therapy (Esim et al.).
Since the discovery of liposomes, tremendous advances have been made in the area of novel drug delivery systems of active
biomolecules. In recent years, the use of liposomes as potential drug delivery carriers has received great attention for drug targeting
to specific cells. These nanosized vesicles offer several advantages such as biocompatibility, biodegradability, low toxicity,
drug delivery efficiency, nonimmunogenicity, and enhancement in solubility, bioavailability and therapeutic efficacy with
their ability to encapsulate wide variety of therapeutic agents. Liposomes have great potential for payloads and for delivery to
targeted sites, which could be helpful in targeting various chemotherapeutic agents to target organs for effective drug targeting.
These nano vesicles can also promote sustained and controlled drug delivery system of therapeutic agents by improving their
pharmacokinetic and pharmacodynamics profiles. Recently, various researches witnessed advancements in the liposomal-based
drug delivery system for potential drug targeting. In this full-thematic issue of the Current Drug Delivery, the application of
liposomal based drug delivery approaches for drug targeting is described from different points of view by various researchers
belong to different regions of the world.
The thematic issue starts with the paper by Alanazi et al., who described the status of lipoproteins-nanocarriers as a promising
approach for targeting liver cancer. This review by Alanazi et al., mainly focused on the diagnosis of liver cancer, available
treatment strategies, use of lipoproteins-nanocarriers in cancer targeting, their preparation, mechanism and their potential applications
in the treatment of liver cancer .
Anjum et al., explored the application of nanoethosomal transgel of naproxen sodium for the treatment of rheumatoid arthritis.
Prepared nanoethosomal tarnsgels of naproxen sodium were characterized physicochemically and evaluated for in vitro
drug release, ex vivo permeation and in vivo pharmacodynamics studies. The optimized nanoethosomal formulation of naproxen
sodium showed good in vitro release, higher ex vivo permeation and in vivo pharmacodynamics effects. The authors of this paper
concluded that nanoethosomal gel of naproxen sodium could be an alternative approach for the treatment of rheumatoid
In another report, Alanazi et al., investigated the liposomal formulation of 5-flurouracil (5-FU) and cholesterol-conjugate of
5-fluorouracil (5-FUC) for liver cancer targeting. 5-FU and 5-FUC loaded liposomes were prepared using a thin-film hydration
method and optimized based on cholesterol ratio and phospholipid type to achieve potential effects for the treatment of liver
cancer. The results of this study suggested that 5-FUC loaded liposomes could be used as an alternative approach to enhance
the therapeutic index of 5-FU and paved the way for potential clinical applications .
A mechanistic approach for liposomal drug delivery system of a bioflavonoid quercetin has been described for cancer targeting
by Das et al. In this review, authors have focused on the mechanisms associated with the anticancer activity of quercetin
and discussed the promising activity of quercetin loaded liposomal drug delivery system as a potent chemotherapeutic agent for
cancer targeting .
El Maghraby and Arafa explored the applications of liposomes for enhanced cellular uptake of anticancer drugs. They have
focused on the modification of liposomal moieties for enhanced cellular uptake of chemotherapeutic agents. This review mainly
outlined the different approaches employed for liposomes modification for enhancing cellular uptake of chemotherapeutic
Misra et al., summarized the scope and challenges of vesicular-carrier mediated delivery of docetaxel for the treatment and
management of cancer. They stated that chemotherapy had vital role in the management of cancer. This review article mainly
highlighted the advances in the delivery of taxanes, in particular docetaxel, with an emphasis on the need, success and pharmacoeconomic
aspects of such vesicular-carrier mediated docetaxel delivery .
This special issue of Current Drug Delivery combines the research topics presented during Controlled Release Asia Meeting
2018 in Singapore (24th & 25th September 2018, Venue: Matrix Building – Biopolis, Singapore), hosted by the Australian chapter
of Controlled Release Society, co-organized and supported by Core-NET (Controlled Release and Encapsulation Network
led by Agency for Science, Technology and Research (A*STAR) at Singapore) and regional Chapters of the Controlled Release
Society. The issue is entitled “Drug Delivery Asia”; however, the content is not limited to the Asian research. The meeting provided
an excellent opportunity for knowledge exchange between participants from Asia and around the world. This issue contains
contributions from a variety of areas in the field of drug and vaccine delivery.
The large number of biological active compounds failed to be developed into drugs due to their poor bioavailability .
Many of them, like genes, peptides and proteins, are too large and too hydrophilic to pass biological membranes . Especially,
oral absorption and poor in vivo stability are major hurdles that have to be overcome for biological active compounds to reach
clinical trials [3, 4]. Problem with off target delivery of drugs is the other common hindrance. To overcome all these obstacles
variety of drug and vaccine delivery systems have been developed. The drug and vaccine candidates can be modified by conjugation
with lipidic moieties to balance their hydrophobicity resulting in improved passive diffusion and uptake into the lymphatic
system [5-7]. In contrast, the saccharide moieties can be conjugates to reduce excessive hydrophobicity of compounds
and improve their water-solubility, or to utilise active transport systems using certain receptors ability to recognize saccharides
and uptake them into the cells, or utilize to target the drug to the desired site of action [8-11]. Improved bioavailability of the
large or hydrophilic molecules can be also achieved with the help of formulations and by the use of cell penetrating peptides
[12, 13], surfactants [14, 15], or polyelectrolytes (such as alginate or chitosan) [16-19]. Nanotechnology-based approaches are
also becoming extensively popular in the drug and vaccine delivery field [20-22]. These strategies take advantage of nanomaterials
ability to a) selectively deliver a therapeutic agent to the desired tissue [23, 24], b) protect a cargo from harsh environment
(e.g. in stomach) and enzymatic degradation (in intestine, blood) [25, 26], c) improve compounds uptake by immune cells when
desired, or reduce this uptake [27, 28], d) allow variety of delivery pathways including oral [29, 30], intranasal [31-33] and intradermal
[17, 34, 35].
This Current Drug Delivery issue comprises both original research reports and review papers focused on the various aspects
of delivery systems mentioned above. The review articles describe the role of carbohydrates in vaccine delivery and development
(Aljohani et al.), as well as targeted gene delivery (Begum et al.). Intraperitoneal (Padmakumar et al.) and oral (Hussain
et al.) delivery strategies of the common chemotherapeutic agent paclitaxel are discussed. The original research articles describe
also the utilization of nanotechnology in amphotericin delivery (Tiyaboonchai et al.) and application of magnetic nanoparticles
for tracking inflammation in the epileptic rat brain (Eyal et al.). The role of polysaccharide chitosan in nanoparticlesbased
drug delivery (Hamid et al. and Sahudin et al.) and the application of lipophilic tocopherol-based carrier for co-enzyme
Q10 formulation (Boyd et al.) are also presented. Finally, oral delivery of antibiotic sirolimus (C.) and the role of mucilages as
pharmaceutical excipients (Gugulothu et al.) are investigated.
These variety of research topics should make this issue of special interest for all the readers of Current Drug Delivery.
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