AP-1 a Target for Cancer Prevention

Author(s): Connie P. Matthews, Nancy H. Colburn, Matthew R. Young

Journal Name: Current Cancer Drug Targets

Volume 7 , Issue 4 , 2007

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The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.

Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation

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Article Details

Year: 2007
Page: [317 - 324]
Pages: 8
DOI: 10.2174/156800907780809723
Price: $65

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