Glycosyltransferase and Glypiation Inhibitors

Author(s): Evelyne Walker-Nasir, Ishtiaq Ahmad, Muhammad Saleem, Daniel C. Hoessli

Journal Name: Current Organic Chemistry

Volume 11 , Issue 7 , 2007

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Abstract:

Understanding the chemistry and biology of protein glycosylation is a major challenge in proteomics and glycomics research. Due to their pivotal role in the biosynthesis of complex oligosaccharides and glycoconjugates, protein glycosylation enzymes are targets of choice for the development of inhibitors. Glycosyltransferase and glypiation (GPI anchoring) inhibitors that are of potential therapeutic value for the treatment of diseases associated with glycosylation defects are reviewed in the light of recent developments.

Keywords: hydroxyproline, uronic acid, neuraminic acid, N-acetylgalactosamine, Congenital disorders of glycosylation, Glypiation

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Article Details

VOLUME: 11
ISSUE: 7
Year: 2007
Page: [591 - 607]
Pages: 17
DOI: 10.2174/138527207780598837
Price: $58

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