Animal Models to Study Plaque Vulnerability

Author(s): K. Schapira, S. Heeneman, M. J. A.P. Daemen

Journal Name: Current Pharmaceutical Design

Volume 13 , Issue 10 , 2007

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The need to identify and characterize vulnerable atherosclerotic lesions in humans has lead to the development of various animal models of plaque vulnerability. In this review, current concepts of the vulnerable plaque as it leads to an acute coronary event are described, such as plaque rupture, erosion, intraplaque hemorrhage and neovascularization. Recently developed animal models that have attempted to reproduce these concepts are described and evaluated based on their suitability in the study of vulnerable plaques. Although certain features of plaque vulnerability have been reported in animal models, a model encompassing all aspects of the vulnerable plaque is lacking.

Keywords: intravascular ultrasound, smooth muscle cell, matrix metalloproteinases, phagocytes, atherosclerosis

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Article Details

Year: 2007
Page: [1013 - 1020]
Pages: 8
DOI: 10.2174/138161207780487575
Price: $65

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