Longevity Genomics Across Species

Author(s): Matt Kaeberlein

Journal Name: Current Genomics

Volume 8 , Issue 2 , 2007


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Abstract:

Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determine life span in one or both organisms. Key pathways have been uncovered linking nutrient and growth factor cues to longevity. Quantitative measures of the degree to which aging is evolutionary conserved are now possible. A major challenge for the future is determining which of these genes play a similar role in human aging and using that information to develop therapies toward age-associated diseases.

Keywords: Caenorhabditis elegans, Saccharomyces cerevisiae, genomic RNAi longevity screens, ambiguous life span, TOR kinases

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2007
Published on: 01 March, 2012
Page: [73 - 78]
Pages: 6
DOI: 10.2174/138920207780368196
Price: $65

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