Abstract
Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determine life span in one or both organisms. Key pathways have been uncovered linking nutrient and growth factor cues to longevity. Quantitative measures of the degree to which aging is evolutionary conserved are now possible. A major challenge for the future is determining which of these genes play a similar role in human aging and using that information to develop therapies toward age-associated diseases.
Keywords: Caenorhabditis elegans, Saccharomyces cerevisiae, genomic RNAi longevity screens, ambiguous life span, TOR kinases
Current Genomics
Title: Longevity Genomics Across Species
Volume: 8 Issue: 2
Author(s): Matt Kaeberlein
Affiliation:
Keywords: Caenorhabditis elegans, Saccharomyces cerevisiae, genomic RNAi longevity screens, ambiguous life span, TOR kinases
Abstract: Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determine life span in one or both organisms. Key pathways have been uncovered linking nutrient and growth factor cues to longevity. Quantitative measures of the degree to which aging is evolutionary conserved are now possible. A major challenge for the future is determining which of these genes play a similar role in human aging and using that information to develop therapies toward age-associated diseases.
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Cite this article as:
Kaeberlein Matt, Longevity Genomics Across Species, Current Genomics 2007; 8 (2) . https://dx.doi.org/10.2174/138920207780368196
DOI https://dx.doi.org/10.2174/138920207780368196 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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