Indoleamine 2,3-Dioxygenase in Materno-Fetal Interaction

Author(s): Peter Sedlmayr

Journal Name: Current Drug Metabolism

Volume 8 , Issue 3 , 2007

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The mechanism of maternal immunotolerance of the semiallogeneic fetus has been a matter of intense investigation. The tryptophan- degrading enzyme indoleamine 2,3-dioxygenase (IDO) is reported to be critically implicated. This article discusses findings pertaining to the role of IDO in pregnancy, its location at the feto-maternal interface, systemic induction of IDO in pregnancy and the association of IDO to spontaneous abortion and preeclampsia. Whereas there is a large body of evidence supporting the relevance of IDO as a key immunoregulatory factor in feto-maternal tolerance, open questions remain concerning as to its role.

Keywords: Feto-maternal tolerance, tryptophan catabolism, placenta, trophoblast, decidua, preeclampsia, spontaneous abortion

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Article Details

Year: 2007
Page: [205 - 208]
Pages: 4
DOI: 10.2174/138920007780362491
Price: $65

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