The IGF-I Axis in Thyroid Carcinoma

Author(s): A. Ciampolillo, C. De Tullio, E. Perlino, E. Maiorano

Journal Name: Current Pharmaceutical Design

Volume 13 , Issue 7 , 2007

Become EABM
Become Reviewer


Insulin like-growth factor I (IGF-I) has been involved in the pathogenesis of a variety of human neoplasia due to the mitogenic and anti-apoptotic properties of its cognate receptor. In human thyroid carcinomas, we have previously documented an increased immunoreactivity of both IGF-I and the IGF-I receptor (IGF-I R) associated with up regulation of IGF-I mRNA . Immunoreactivity of IGF-I and cognate receptor positively correlated with tumor diameter and wide intrathyroidal extension but not with patients gender and age or with the stage of the tumors and the occurrence of limph node metastases. Most experimental studies indicate that the effects of IGF-I on target cells are regulated in a complex fashion and depend on the simultaneous occurrence of IGF-IR and the binding proteins.

Keywords: IGF-I, IGF-I receptor, thyroid carcinoma

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Page: [729 - 735]
Pages: 7
DOI: 10.2174/138161207780249209
Price: $65

Article Metrics

PDF: 2