Reproducibility and Scalability of Solvent-Free Microwave-Assisted Reactions:From Domestic Ovens to Controllable Parallel Applications

Author(s): Angel Diaz-Ortiz, Antonio de la Hoz, Jesus Alcazar, Jose Ramon Carrillo, Maria Antonia Herrero, Alberto Fontana, Juan de Mata Munoz

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 10 , Issue 3 , 2007

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Abstract:

The heating of different parallel arrays in domestic ovens offers the possibility to perform multiple reactions in one irradiation experiment, blending the advantages of microwave heating technology and parallel chemistry. However, they are usually performed without an appropriate temperature control; thus, reproducibility becomes a major issue limiting the application of such reactions. This is exemplified when working at a different scales or using different instruments. For the first time a typical solvent-free reaction described in a domestic oven has been reproduced in monomode reactor, scaled up in a controlled multimode oven and reproduced in parallel, 24 reactions were carried out in a well plate. Parallel reactions were performed in a Weflon® multiwell plate to assure identical conditions for each individual reaction. As many reactions under microwave irradiation have been performed in solvent-free conditions, this result opens new possibilities in reproducibility, scalability and combinatorial chemistry and permits to take advantage of many synthetic procedures described in domestic ovens.

Keywords: multimode microwave ovens, Nitrile N-Oxide 1, HPLC, MicroSYNTH labstation multimode microwave oven (MILESTONE), Monomode microwave irradiations

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2007
Page: [163 - 169]
Pages: 7
DOI: 10.2174/138620707780126679
Price: $65

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