The Vascular Compartments of Neovascularization: Spotlight on the Microcirculation

Author(s): Christian Kupatt

Journal Name: Current Pharmaceutical Biotechnology

Volume 8 , Issue 1 , 2007

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In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given the viability of the parenchyma. In particular, a chain of microcirculatory events will be described which - after specific endothelial activation by growth factors – enhances capillary and microcirculatory vessel formation, Backward signalling is introduced as potential mechanism to induce collateral growth, recruiting pre-existent macrovessel networks for blood supply to the increased microcirculatory cross sectional area. Potential signal cascades will be discussed.

Keywords: Angiogenesis, arteriogenesis, vasculogenesis, VEGF, eNOS, endothelial progenitor cells, vessel maturation, inflammation

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Article Details

Year: 2007
Published on: 01 March, 2012
Page: [27 - 33]
Pages: 7
DOI: 10.2174/138920107779941390

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