Immobilized Polysaccharide CSPs: An Advancement in Enantiomeric Separations

Author(s): Imran Ali, Hassan Y. Aboul-Enein

Journal Name: Current Pharmaceutical Analysis

Volume 3 , Issue 1 , 2007

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With the advancement of science and technology chiral chromatography has achieved an important place in analytical science. Coated polysaccharide chiral stationary phases (CSPs) are most popular due to their high chiral recognition power. But during last few years, immobilization of polysaccharide derivatives with silica gel has opened new realms in this area as these CSPs can be used with normal and prohibited solvents (tetrahydrofuran, chloroform, dichloromethane, acetone, 1,4-dioxane, ethylacetate, and certain other ethers). The present article describes status and method protocol of immobilized polysaccharides CSPs for the chiral resolution of different racemates using liquid chromatography. The contents of this article include methods of immobilization, their applications under optimized conditions, enantioselectivities, efficiencies and a comparison of the chiral recognition capabilities of coated vs immobilized CSPs.

Keywords: Radical Polymerization, Immobilization, Chiralpak AD columns, tetrahydrofuran (THF), Amylose and Cellulose Immobilized CSPS

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Article Details

Year: 2007
Page: [71 - 82]
Pages: 12
DOI: 10.2174/157341207779802368

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