Multiple Functions of Rad9 for Preserving Genomic Integrity

Author(s): Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito, Keiichi Ichimura

Journal Name: Current Genomics

Volume 7 , Issue 8 , 2006

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Abstract:

DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preserving genomic integrity, plays multiple roles in fundamental biological processes, including the regulation of the DNA damage response, cell cycle checkpoint control, DNA repair, apoptosis, transcriptional regulation, exonuclease activity, ribonucleotide synthesis and embryogenesis. This review examines work that provides significant insight into the molecular mechanisms of several individual cellular processes which might be beneficial for developing novel therapeutic approaches to cancerous diseases with genomic instability.

Keywords: DNA damage, replication, checkpoint, cancer

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Article Details

VOLUME: 7
ISSUE: 8
Year: 2006
Page: [477 - 480]
Pages: 4
DOI: 10.2174/138920206779315746
Price: $65

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