PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug

Author(s): P. Vijayaraj Kumar, Hrushikesh Agashe, Tathagata Dutta, Narendra K. Jain

Journal Name: Current Drug Delivery

Volume 4 , Issue 1 , 2007

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The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non- PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.

Keywords: Dendrimers, PEGylation, micelles, rifampicin, prolonged release

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Article Details

Year: 2007
Page: [11 - 19]
Pages: 9
DOI: 10.2174/156720107779314794

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PDF: 33