Nitric Oxide and the Regulation of Apoptosis in Tumour Cells

Author(s): J. M. Tarr, P. Eggleton, P. G. Winyard

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 34 , 2006

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Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.

Keywords: Nitric Oxide, Apoptosis, Nitric Oxide Synthase, Tumour Cells

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Article Details

Year: 2006
Page: [4445 - 4468]
Pages: 24
DOI: 10.2174/138161206779010477
Price: $65

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