Abstract
The RB gene was discovered 20 years ago because of its role in the childhood eye cancer retinoblastoma. However, surprisingly little progress was made in defining the role of RB protein in the retina. In the last two years, new models exploiting conditional deletion of the mouse Rb gene have altered this picture radically. These models provide insight into the first Rb function, the cell of origin of retinoblastoma, the window during which Rb acts, distinct cell-specific defenses against Rb loss, the number and type of post-Rb lesions required for transformation, why pediatric tumors exist, the controversial role of the p53 pathway in retinoblastoma, and the reason why the disease is virtually unique to humans. Two years have dramatically improved our understanding of Rb function in the tissue that gave us this important tumor suppressor.
Keywords: mouse embryo fibroblasts (MEFs), Retinal Transition Cells, Viral Oncoproteins, Germline Knock-Out Mice, Chx10-Cre Mice
Current Molecular Medicine
Title: Insights from Animal Models on the Origins and Progression of Retinoblastoma
Volume: 6 Issue: 7
Author(s): Marek Pacal and Rod Bremner
Affiliation:
Keywords: mouse embryo fibroblasts (MEFs), Retinal Transition Cells, Viral Oncoproteins, Germline Knock-Out Mice, Chx10-Cre Mice
Abstract: The RB gene was discovered 20 years ago because of its role in the childhood eye cancer retinoblastoma. However, surprisingly little progress was made in defining the role of RB protein in the retina. In the last two years, new models exploiting conditional deletion of the mouse Rb gene have altered this picture radically. These models provide insight into the first Rb function, the cell of origin of retinoblastoma, the window during which Rb acts, distinct cell-specific defenses against Rb loss, the number and type of post-Rb lesions required for transformation, why pediatric tumors exist, the controversial role of the p53 pathway in retinoblastoma, and the reason why the disease is virtually unique to humans. Two years have dramatically improved our understanding of Rb function in the tissue that gave us this important tumor suppressor.
Export Options
About this article
Cite this article as:
Pacal Marek and Bremner Rod, Insights from Animal Models on the Origins and Progression of Retinoblastoma, Current Molecular Medicine 2006; 6 (7) . https://dx.doi.org/10.2174/1566524010606070759
DOI https://dx.doi.org/10.2174/1566524010606070759 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs
Current Medicinal Chemistry Cancer Metastasis: Characterization and Identification of the Behavior of Metastatic Tumor Cells and the Cell Adhesion Molecules, including Carbohydrates
Current Drug Targets - Cardiovascular & Hematological Disorders Subject Index To Volume 8
Current Pharmaceutical Design The Cardiovascular Nutrapharmacology of Resveratrol: Pharmacokinetics, Molecular Mechanisms and Therapeutic Potential
Current Medicinal Chemistry Targeting Antioxidants to Mitochondria: A Potential New Therapeutic Strategy for Cardiovascular Diseases
Current Pharmaceutical Design Nanoparticles in Cancer
Current Radiopharmaceuticals Development of Novel Therapeutic Drugs in Humans from Plant Antimicrobial Peptides
Current Protein & Peptide Science Killing the Messenger: Antisense DNA and siRNA
Current Drug Targets Gene and Cancer Therapy - Pseudorabies Virus: A Novel Research and Therapeutic Tool?
Current Gene Therapy Induced Pluripotent Stem Cells (iPSCs) Derived from Different Cell Sources and their Potential for Regenerative and Personalized Medicine
Current Molecular Medicine Editorial [Hot Topic:Protein targets for development of drugs against Mycobacterium tuberculosis (Guest Editor: Walter Filgueira de Azevedo)]
Current Medicinal Chemistry Recent Inventions on Receptor Tyrosine Kinase RET Modulation
Recent Patents on Biotechnology Efficacy and Safety of Robot-assisted Thoracic Surgery (RATS) Compare with Video-assisted Thoracoscopic Surgery (VATS) for Lung Lobectomy in Patients with Non-small Cell Lung Cancer
Combinatorial Chemistry & High Throughput Screening Scientific and Clinical Challenges in Sepsis
Current Pharmaceutical Design Carotenoids of Microalgae Used in Food Industry and Medicine
Mini-Reviews in Medicinal Chemistry Bioadhesive Films as Drug Delivery Systems
Drug Delivery Letters RAGE and its Ligands in Retinal Disease
Current Molecular Medicine Cytochromes P450 in the Bioactivation of Chemicals
Current Topics in Medicinal Chemistry A Machine Learning-based Diagnosis of Thyroid Cancer Using Thyroid Nodules Ultrasound Images
Current Bioinformatics Effects of Plant Extracts on HIV-1 Protease
Current HIV Research