The Role of Adipocytokines and Neurohormonal Dysregulation in Metabolic Syndrome


Journal Name: Current Diabetes Reviews

Volume 2 , Issue 4 , 2006

Become EABM
Become Reviewer
Call for Editor


Metabolic syndrome, also known as the insulin resistance syndrome (IRS), dysmetabolic syndrome or syndrome X, is a burgeoning global epidemic. This constellation of risk factors, namely glucose intolerance, hypertension, dyslipidemia (high triglyceride and low HDL cholesterol), central obesity, pro-inflammatory and prothrombotic state, culminating to the development of premature cardiovascular and renal disease, has significant impact on life expectancy, societal productivity and quality of life. The underlying mechanism of this complex syndrome remains to be elucidated. In recent years, light has been shed on the roles of neuroendocrine system and adipocytokines on the pathogenesis of IRS. In this review, we summarize the possible links between insulin and various hormones (growth hormones (GH), catecholamines, glucocorticoids and sex hormones), partly mediated through visceral adiposity and adipocytokines (notably adiponectin, leptin, resistin, visfatin, tumor necrosis factor α (TNF-α), interleukin-6 (IL-6)) in the pathogenesis of this syndrome.

Keywords: Adipocytokines, Neurohormonal Dysregulation, Insulin Resistance Syndrome, Metabolic Syndrome

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [397 - 407]
Pages: 11
DOI: 10.2174/1573399810602040397
Price: $65

Article Metrics

PDF: 2