Nucleic Acids Modulate Autoimmunity Through Nucleic-Acid-Specific Toll-Like Receptors


Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 25 , 2006

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Autoimmune diseases are believed to develop mainly from three factors comprising genetic predisposition, environmental factors and immune (dys-) regulation. In this context, specific nucleic acids of exogenous or endogenous origin that signal through nucleic acid-specific Toll-like receptors (TLRs) have gained much research attention. During ongoing autoimmune disease microbial nucleic acids contribute to flares of disease and its aggravation leading to end organ damage, through unfavourable immune modulation. Apart from exogenous sources, nucleic acid molecules of endogenous origin emerge as potential ligands for receptors of host defence, i.e. TLRs. Rapidly accumulating data on the role of nucleic acid-specific TLRs has not only provided insights about their pathogenic potential of endogenous nucleic acid molecules, but is also fuelling the development of novel immunotherapies.

Keywords: Autoimmunity, lupus, Toll-like receptors, Inhibitory oligonucleotides, Immunoregulatory sequences

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Article Details

Year: 2006
Page: [3061 - 3067]
Pages: 7
DOI: 10.2174/092986706778521832
Price: $65

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