Abstract
In the last decades, the physiological and pharmacological properties of dopamine receptors were controversial principally because of the lack of selective ligand for some receptor subtypes. Since 1997, some specific D4 agonists have been described and have allowed a therapeutic approach. We report here, compounds described as D4 agonist and when available the SAR. The major studies for physiological implications and their potential biological applications are also reported and principally their interest in erectile dysfunction.
Keywords: D4 agonist, 3-phenylpiperidines, 4-phenylpiperazines, penile erection
Current Medicinal Chemistry
Title: Recent Progress in Medicinal Chemistry of D4 Agonists
Volume: 13 Issue: 25
Keywords: D4 agonist, 3-phenylpiperidines, 4-phenylpiperazines, penile erection
Abstract: In the last decades, the physiological and pharmacological properties of dopamine receptors were controversial principally because of the lack of selective ligand for some receptor subtypes. Since 1997, some specific D4 agonists have been described and have allowed a therapeutic approach. We report here, compounds described as D4 agonist and when available the SAR. The major studies for physiological implications and their potential biological applications are also reported and principally their interest in erectile dysfunction.
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Cite this article as:
Recent Progress in Medicinal Chemistry of D4 Agonists, Current Medicinal Chemistry 2006; 13 (25) . https://dx.doi.org/10.2174/092986706778521841
DOI https://dx.doi.org/10.2174/092986706778521841 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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