Molecular Characteristics of Autoimmune Pancreatitis

Author(s): Robert Jaster, Jorg Emmrich

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 29 , 2006

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For many years, a pathological immune response has been implicated in the development of chronic pancreatitis. However, only in the last decade autoimmune pancreatitis (AIP) has been recognized as a distinct entity with typical histopathological and immunological findings. AIP is frequently associated with other autoimmune diseases, such as Sjogrens syndrome, sclerosing extra-hepatic cholangitis and retroperitoneal fibrosis. Although AIP is rare, improved diagnostics is of significant clinical interest because of the prompt response to steroid treatment. In this review, we describe the characteristic features of AIP and focus on the molecular pathogenesis of the disease.

Keywords: Autoimmune pancreatitis, molecular pathogenesis

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Article Details

Year: 2006
Page: [3781 - 3786]
Pages: 6
DOI: 10.2174/138161206778559812
Price: $65

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