Recent Advances in the Treatment of Multiple Myeloma

Author(s): Hiroshi Yasui, Teru Hideshima, Paul G. Richardson, Kenneth C. Anderson

Journal Name: Current Pharmaceutical Biotechnology

Volume 7 , Issue 5 , 2006

Become EABM
Become Reviewer
Call for Editor


Multiple Myeloma (MM) remains an incurable plasma cell malignancy in the bone marrow (BM) despite conventional therapies as well as high-dose therapies with stem cell support. Therefore novel biologically-based therapeutic approaches are required. Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in MM. In particular, recognition of the biologic significance of the BM microenvironment in MM pathogenesis and as a potential target for novel therapeutics has derived several promising approaches. Novel FDA approved agents including thalidomide/thalomid®, its immunomodulatory derivatives lenalidomide/Revlimid®, and proteasome inhibitor bortezomib/Velcade® are directed at molecular targets not only in MM cells but also in its BM milieu, and have already achieved promising results in clinical studies. Here we discuss the mechanisms of action of these novel drugs and their clinical application, alone or combined with conventional or novel drugs.

Keywords: bone marrow stromal cells, VEGF, IL-6, Cytokines, fibroblast growth factor (bFGF), Cancer Therapy, proteasome inhibitor

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [381 - 393]
Pages: 13
DOI: 10.2174/138920106778521569
Price: $65

Article Metrics

PDF: 3