Targeting the Oncogenic Tyrosine Kinase NPM-ALK in Lymphoma: The Role of Murine Models in Defining Pathogenesis and Treatment Options

Author(s): Cornelius Miething, Christian Peschel, Justus Duyster

Journal Name: Current Drug Targets

Volume 7 , Issue 10 , 2006

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Oncogenic tyrosine kinases play a ever growing role in the pathogenesis of human malignancies. In human non-hodgkin lymphomas, the NPM-ALK oncogene arising from the t(2;5) chromosomal translocation represents the most important oncogenic tyrosine kinase identified so far. The ALK-kinase is constitutively activated by NPM-induced dimerization and signals through a multitude of growth promoting and antiapoptotic pathways. Murine models have made a significant impact on the elucidation of the molecular pathogenesis and new treatment options of malignant diseases. Here, the latest developments in the analysis of NPM-ALK induced lymphomagenesis by murine models is reviewed.

Keywords: oncoprotein, NPM ALK-protein expression, malignancy, CD 30, xenograft model

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Article Details

Year: 2006
Page: [1329 - 1334]
Pages: 6
DOI: 10.2174/138945006778559229
Price: $65

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PDF: 6