Abstract
The state of the art for the enantio-differentiating hydrogenation over an asymmetrically modified nickel catalyst is reviewed along with the background development of the catalyst. An enantioselectivity up to 98% was obtained for the hydrogenation of β-functionalized ketones. The durability of the enantioselectivity was significantly improved using an in-situ-modified nickel powder catalyst (80-90% enantioselectivity for over 20 runs). Recent mechanistic investigations based on surface science are also summarized for the discussion of the enantio-differentiating model.
Keywords: bitartrate molecules, Enantio-Differentiation Model, non-selective hydrogenation, 2-alkanones, Supported Ni catalysts
Current Organic Chemistry
Title: Asymmetrically Modified Nickel Catalyst for the Enantio-Differentiating Hydrogenation of Prochiral Ketones
Volume: 10 Issue: 13
Author(s): T. Osawa, T. Harada and O. Takayasu
Affiliation:
Keywords: bitartrate molecules, Enantio-Differentiation Model, non-selective hydrogenation, 2-alkanones, Supported Ni catalysts
Abstract: The state of the art for the enantio-differentiating hydrogenation over an asymmetrically modified nickel catalyst is reviewed along with the background development of the catalyst. An enantioselectivity up to 98% was obtained for the hydrogenation of β-functionalized ketones. The durability of the enantioselectivity was significantly improved using an in-situ-modified nickel powder catalyst (80-90% enantioselectivity for over 20 runs). Recent mechanistic investigations based on surface science are also summarized for the discussion of the enantio-differentiating model.
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Cite this article as:
Osawa T., Harada T. and Takayasu O., Asymmetrically Modified Nickel Catalyst for the Enantio-Differentiating Hydrogenation of Prochiral Ketones, Current Organic Chemistry 2006; 10 (13) . https://dx.doi.org/10.2174/138527206778249676
DOI https://dx.doi.org/10.2174/138527206778249676 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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