Abstract
Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the relatively lower cytotoxicity. Phenothiazines have been used for clinical treatments as psychotropics. In contrast to the psychotropic preparations, their information of other biological activities of phenothiazines and their related compounds has been limited. This review article summarizes the interaction with DNA (using quantum calculation), antitumor activity, differentiation or apoptosis-inducing activity, tumor necrosis factor (TNF)-induction, antiproliferative activity, radical scavenging activity, antimutagenic activity, antiplasmid activity, antibacterial activity, reversal of multidrug resistance (MDR), blast transformation activity of phenothiazines, benz[c]acridines and benzo[a]phenothiazines.
Keywords: Antitumor, Radical Scavenging Activity, Tumor Necrosis Factor (TNF), CPZ-nucleotide systems, AIDS, Blast Transformation
Current Drug Targets
Title: Cytotoxic Potential of Phenothiazines
Volume: 7 Issue: 9
Author(s): Noboru Motohashi, Masami Kawase, Kazue Satoh and Hiroshi Sakagami
Affiliation:
Keywords: Antitumor, Radical Scavenging Activity, Tumor Necrosis Factor (TNF), CPZ-nucleotide systems, AIDS, Blast Transformation
Abstract: Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the relatively lower cytotoxicity. Phenothiazines have been used for clinical treatments as psychotropics. In contrast to the psychotropic preparations, their information of other biological activities of phenothiazines and their related compounds has been limited. This review article summarizes the interaction with DNA (using quantum calculation), antitumor activity, differentiation or apoptosis-inducing activity, tumor necrosis factor (TNF)-induction, antiproliferative activity, radical scavenging activity, antimutagenic activity, antiplasmid activity, antibacterial activity, reversal of multidrug resistance (MDR), blast transformation activity of phenothiazines, benz[c]acridines and benzo[a]phenothiazines.
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Cite this article as:
Motohashi Noboru, Kawase Masami, Satoh Kazue and Sakagami Hiroshi, Cytotoxic Potential of Phenothiazines, Current Drug Targets 2006; 7 (9) . https://dx.doi.org/10.2174/138945006778226624
DOI https://dx.doi.org/10.2174/138945006778226624 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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