Cellular Mechanisms and Prospective Applications of Hypericin in Photodynamic Therapy

Author(s): Tobias Kiesslich, Barbara Krammer, Kristjan Plaetzer

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 18 , 2006

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During the last decades, Photodynamic Therapy (PDT) has been established as a powerful alternative approved by health agencies of several countries for treatment of various malignant and some non-malignant diseases. PDT makes use of the light-induced destruction of target cells by formation of cytotoxic products in the presence of a photosensitizing agent and oxygen. The light-dependent tumor destructive properties of Hypericin have drawn attention to its promising application as a photosensitizer in the frame of PDT. Hypericin is a naturally occurring secondary metabolite in plants of the Hypericum genus, with Hypericum perforatum (St. Johns wort) as it is a commonly known representative. This review focuses on the cellular mechanisms of Hypericin-based phototoxicity and provides an outlook for future application of Hypericin as a fluorescing and photosensitizing agent for diagnosis and treatment of cancerous diseases, respectively.

Keywords: Photodynamic Therapy, Hypericin, Clinical anti-cancer treatment, Apoptosis, Cell death mechanisms, Photophysical Diagnosis

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Article Details

Year: 2006
Page: [2189 - 2204]
Pages: 16
DOI: 10.2174/092986706777935267
Price: $65

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