Abstract
Historically, oxidative stress was recognized to contribute to cancer development uniquely by induction of genomic instability. However, recent research has provided multiple evidence that reactive oxygen species and other free radicals, such as nitric oxide, often produced at elevated levels within tumor tissue, may function as signaling molecules that initiate and/or modulate the different regulatory pathways involved in tumorigenesis and metastasis. This review will focus on the complex role of oxidative stress and redox signaling in cancer neovascularization, a process without which the tumor is unable to grow beyond few millimeters in size. Reactive oxygen species and nitric oxide affect cell responses to hypoxia, a major trigger of angiogenic switch in tumors and are important upstream regulators as well as downstream mediators of action of the most potent proangiogenic factor - vascular endothelial growth factor. We will discuss targeting the redox-regulated mechanisms for antiangiogenic anticancer therapy and focus on recent developments in small-molecule agents that have either completed clinical trials or show a great promise to be subjected to them. Modulation of redox species production, signaling and metabolism and/or manipulating cellular antioxidant responses represents a multitargeted therapeutic approach which may possibly overcome the limitations of single-agent antiangiogenic treatments and potentiate effects of standard methods.
Keywords: Tumor angiogenesis, oxidative stress, antiangiogenic therapy, reactive oxygen species, nitric oxide, small-molecule angiogenesis inhibitors, VEGF, hypoxia, sorafenib, sunitinib, E3 ubiquitin, factor inhibiting HIF, ETC, ascorbate, SnPPIX, HUVEC, TSP-1, Vasculogenesis, VASP, NOXs, angiotensin, VAS2870, PTK787, vatalanib, Thymidine Phosphorylase, trifluorothymidine, flavopiridol, fibrosarcoma, glioma, NSCLC, ZnPPIX treatment
Current Pharmaceutical Design
Title: Oxidative Stress in Tumor Angiogenesis - Therapeutic Targets
Volume: 16 Issue: 35
Author(s): Magdalena Tertil, Alicja Jozkowicz and Jozef Dulak
Affiliation:
Keywords: Tumor angiogenesis, oxidative stress, antiangiogenic therapy, reactive oxygen species, nitric oxide, small-molecule angiogenesis inhibitors, VEGF, hypoxia, sorafenib, sunitinib, E3 ubiquitin, factor inhibiting HIF, ETC, ascorbate, SnPPIX, HUVEC, TSP-1, Vasculogenesis, VASP, NOXs, angiotensin, VAS2870, PTK787, vatalanib, Thymidine Phosphorylase, trifluorothymidine, flavopiridol, fibrosarcoma, glioma, NSCLC, ZnPPIX treatment
Abstract: Historically, oxidative stress was recognized to contribute to cancer development uniquely by induction of genomic instability. However, recent research has provided multiple evidence that reactive oxygen species and other free radicals, such as nitric oxide, often produced at elevated levels within tumor tissue, may function as signaling molecules that initiate and/or modulate the different regulatory pathways involved in tumorigenesis and metastasis. This review will focus on the complex role of oxidative stress and redox signaling in cancer neovascularization, a process without which the tumor is unable to grow beyond few millimeters in size. Reactive oxygen species and nitric oxide affect cell responses to hypoxia, a major trigger of angiogenic switch in tumors and are important upstream regulators as well as downstream mediators of action of the most potent proangiogenic factor - vascular endothelial growth factor. We will discuss targeting the redox-regulated mechanisms for antiangiogenic anticancer therapy and focus on recent developments in small-molecule agents that have either completed clinical trials or show a great promise to be subjected to them. Modulation of redox species production, signaling and metabolism and/or manipulating cellular antioxidant responses represents a multitargeted therapeutic approach which may possibly overcome the limitations of single-agent antiangiogenic treatments and potentiate effects of standard methods.
Export Options
About this article
Cite this article as:
Tertil Magdalena, Jozkowicz Alicja and Dulak Jozef, Oxidative Stress in Tumor Angiogenesis - Therapeutic Targets, Current Pharmaceutical Design 2010; 16 (35) . https://dx.doi.org/10.2174/138161210794454969
DOI https://dx.doi.org/10.2174/138161210794454969 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Turnover Studies on Cardiac Natriuretic Peptides: Methodological,Pathophysiological and Therapeutical Considerations.
Current Drug Metabolism Diet and Heart Health: Moderate Wine Drinking Strengthens the Cardioprotective Effects of Fish Consumption
Current Pharmaceutical Biotechnology Influence of Drugs on Mild Cognitive Impairment in Parkinson’s Disease: Evidence from the PACOS Study
Current Neuropharmacology Geriatric Depression - Review for Primary Care
Current Psychiatry Reviews Hypotensive Agents from Snake Venoms
Current Drug Targets - Cardiovascular & Hematological Disorders Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2
Current Drug Metabolism Hydroxyimine NO-Donors; FK409 and Derivatives
Current Topics in Medicinal Chemistry Geriatric Psychopharmacology in Acute Settings
Current Psychopharmacology A Review of the Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus
Current Pharmaceutical Design Technological Options for the Production of Health-Promoting Proteins and Peptides Derived from Milk and Colostrum
Current Pharmaceutical Design The “Parkinsonian Heart”: From Novel Vistas to Advanced Therapeutic Approaches in Parkinsons Disease
Current Medicinal Chemistry Natural Products Towards the Discovery of Potential Future Antithrombotic Drugs
Current Pharmaceutical Design Catheter Ablation of Lone Atrial Fibrillation
Current Pharmaceutical Design The Vasoactive Role of Nitric Oxide: Physiological and Morphological Aspects
Current Pharmaceutical Biotechnology Synthesis and Characterization of Water-soluble Conjugates of Cabazitaxel Hemiesters-Dextran
Anti-Cancer Agents in Medicinal Chemistry Vascular Dementia: Atherosclerosis, Cognition and Alzheimers Disease
Current Alzheimer Research Current Biological Therapies for Inflammatory Bowel Disease
Current Pharmaceutical Design Modification Strategies of Lipid-Based Nanocarriers for Mucosal Drug Delivery
Current Pharmaceutical Design Natural Products and Cardiovascular Diseases
Current Molecular Pharmacology Chiral Kinase Inhibitors
Current Topics in Medicinal Chemistry