Leptin, Estrogens and Cancer

Author(s): Maria del Carmen Maeso Fortuny, Buenaventura Brito Diaz, Antonio Cabrera de Leon

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 8 , 2006

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Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.

Keywords: Cancer, leptin, estrogen receptors

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Article Details

Year: 2006
Page: [897 - 907]
Pages: 11
DOI: 10.2174/138955706777934973
Price: $65

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