Abstract
Type 2 diabetes is a complex metabolic disease with hyperglycemia as its recognizable hallmark. Hepatic glucose output is elevated in Type 2 diabetic patients, and evidence suggests drugs which lower hepatic glucose production are effective antihyperglycemic agents. Glycogenolysis, which is the release of monomeric glucose from its polymeric storage form called glycogen, is a key contributor to hepatic glucose output. Glycogen phosphorylase is the enzyme that catalyzes this process. This review covers advances in the design of small molecule inhibitors of this enzyme, their biological activity, and their potential as effective antihyperglycemic agents for the treatment of Type 2 diabetes.
Keywords: Glycogen Phosphorylase, Glycogenolysis, Type 2 diabetes, Hepatic glucose output, glycogen phosphorylase inhibitors
Mini-Reviews in Medicinal Chemistry
Title: Glycogen Phosphorylase Inhibitors
Volume: 6 Issue: 8
Author(s): Brad R. Henke and Steven M. Sparks
Affiliation:
Keywords: Glycogen Phosphorylase, Glycogenolysis, Type 2 diabetes, Hepatic glucose output, glycogen phosphorylase inhibitors
Abstract: Type 2 diabetes is a complex metabolic disease with hyperglycemia as its recognizable hallmark. Hepatic glucose output is elevated in Type 2 diabetic patients, and evidence suggests drugs which lower hepatic glucose production are effective antihyperglycemic agents. Glycogenolysis, which is the release of monomeric glucose from its polymeric storage form called glycogen, is a key contributor to hepatic glucose output. Glycogen phosphorylase is the enzyme that catalyzes this process. This review covers advances in the design of small molecule inhibitors of this enzyme, their biological activity, and their potential as effective antihyperglycemic agents for the treatment of Type 2 diabetes.
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Cite this article as:
Henke R. Brad and Sparks M. Steven, Glycogen Phosphorylase Inhibitors, Mini-Reviews in Medicinal Chemistry 2006; 6 (8) . https://dx.doi.org/10.2174/138955706777934991
DOI https://dx.doi.org/10.2174/138955706777934991 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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