Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales

Author(s): Kenneth L. Kirk

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 14 , 2006

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Abstract:

Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.

Keywords: fluorine substitution, 5-Fluorouracil (5-FU), T138067, Hydrolytic stability, cholesterol acyl transferas, monofluorination

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Article Details

VOLUME: 6
ISSUE: 14
Year: 2006
Page: [1447 - 1456]
Pages: 10
DOI: 10.2174/156802606777951073
Price: $65

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