Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Author(s): Vladimira Moulisova, Jiri Sebestian, Olga Jedlickova, Alexandr Jegorov, Stepanka B. Sebestianova

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 6 , 2006

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Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.

Keywords: Cyclosporin A, silymarin flavonoids, hepatocytes, membrane transport

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Article Details

Year: 2006
Page: [429 - 435]
Pages: 7
DOI: 10.2174/157018006777805567
Price: $65

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