Utilization of Ribozymes as Antiviral Agents

Author(s): M. L. Benitez-Hess, L. M. Alvarez-Salas

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 6 , 2006

Become EABM
Become Reviewer


Ribozymes are involved in strategies to block gene expression and have been used as agents against viral infections and cancer. Emphasis has been on studies using hairpin and hammerhead ribozymes. The uniqueness of ribozymes is that they posses multiple turnover allowing high efficiency as antiviral agents. Ribozymes have been directed to human immunodeficiency virus (HIV), hepatitis (B, C and E) and human papillomavirus (HPV), the cause of cervical cancer. The mode of action of antiviral ribozymes, their structure and their in vitro effectiveness as inhibitors of HIV, HBV, HCV, HEV and HPV is reviewed. Although ribozymes have been demonstrated as effective antivirals in cell culture and some animal models, clinical studies have been limited. Nevertheless, ribozymes remain as a viable alternative to antisense and RNA interference

Keywords: Ribozyme, catalytic RNA, antisense, ribonucleic acid, RNA, papillomavirus, AIDS, hepatitis virus, hepadnavirus, HIV, HPV

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [390 - 404]
Pages: 15
DOI: 10.2174/157018006777805521
Price: $65

Article Metrics

PDF: 1