Cyclooxygenases in Cancer: Chemoprevention and Sensitization to Conventional Therapies

Author(s): Y. T. Jeon, Y. S. Song

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 7 , 2006


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Abstract:

We have focused on cyclooxygenase, the key enzyme in prostaglandin synthesis, from our basic knowledge regarding the enzyme, to its clinical application in the field of oncology. We will present evidence that this enzyme is intimately associated with carcinogenesis, invasion, metastasis, and the response of tumors to current therapeutic modalities in a variety of human malignancies. We will also discuss the applications of cyclooxygenase inhibitors tochemoprevention and to the sensitization of tumors to conventional anti-cancer therapies.

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2006
Published on: 01 March, 2012
Page: [827 - 833]
Pages: 7
DOI: 10.2174/138955706777698660
Price: $65

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