Fused 1,4-Dihydropyridines as Potential Calcium Modulatory Compounds

Author(s): Cihat Safak, Rahime Simsek

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 7 , 2006

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1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium antagonistic activity. Fused 1,4-dihydropyridines (DHPs) have also exhibit calcium modulatory activities. In this article, weemphasizecalcium channels and fused 1,4-DHP derivatives affecting calcium channels. In addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.

Keywords: 1,4-Dihydropyridine, hexahydroquinoline, calcium modulatory activity, synthesis, biotransformation, structure-activity relationships

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Article Details

Year: 2006
Page: [747 - 755]
Pages: 9
DOI: 10.2174/138955706777698606
Price: $65

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