Design, Synthesis and Initial In Vitro Evaluation of Novel Prodrugs for the Treatment of Cystinosis

Author(s): R. J. Anderson, D. Cairns, W. A. Cardwell, M. Case, P. W. Groundwater, A. G. Hall, L. Hogarth, A. L. Jones, O. Meth-Cohn, P. Suryadevara

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 5 , 2006


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Abstract:

Simple amino acid prodrugs of cysteamine and cystamine were synthesized to overcome the problems of palatability and gastrointestinal irritation, while γ-glutamyl prodrugs were synthesized to target the parent drug to γ-glutamyl transpeptidase (GGT). Preliminary cystine-depleting evaluation in vitro suggests further investigation is warranted. Low toxicity of the prodrugs was observed.

Keywords: Cystinosis, prodrugs, GGT, cysteamine, cystamine

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [336 - 345]
Pages: 10
DOI: 10.2174/157018006777574258
Price: $65

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