Therapeutic Targeting of Endothelial Dysfunction in Chronic Diabetic Complications

Author(s): Zia A. Khan, Subrata Chakrabarti

Journal Name: Recent Patents on Cardiovascular Drug Discovery
Continued as Recent Advances in Cardiovascular Drug Discovery

Volume 1 , Issue 2 , 2006


In an ever-increasing population of patients with diabetes, morbidity and mortality due to the secondary complications require prompt identification of the underlying mechanisms. Aberration in the vascular endothelial cell function may be a key element in the development and progression of the chronic diabetic complications. We present the hypothesis that preservation and restoration of the endothelial cell function may potentially be the most efficient means of targeting the adverse effects of hyperglycemia.

Keywords: Endothelial cells, diabetes, microangiopathy, macroangiopathy, basement membrane, extracellular matrix, fibronectin, oxidative stress, protein kinase C, aldose reductase

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Article Details

Year: 2006
Page: [167 - 175]
Pages: 9
DOI: 10.2174/157489006777442531
Price: $65

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