HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target

Author(s): Enzo Tramontano

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 6 , 2006


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Abstract:

HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

Keywords: HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids

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Article Details

VOLUME: 6
ISSUE: 6
Year: 2006
Page: [727 - 737]
Pages: 11
DOI: 10.2174/138955706777435733
Price: $65

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