Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases

Author(s): Alex Kiselyov, Konstantin V. Balakin, Sergey E. Tkachenko, Nikolay P. Savchuk

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 6 , 2006

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Abstract:

The majority of marketed and late stage development kinase inhibitors are reported to be ATPcompetitive. As a result, many promising drug candidates display non-specific activity that results in undesired physiological effects. There is growing interest towards non-ATP competitive kinase inhibitors, as they are expected to yield highly specific and efficacious molecules devoid of non-mechanistic toxicity. Recent developments in this area are summarized in our review.

Keywords: Protein kinases, Tyrosine kinases, Serine/threonine kinases, Non-ATP competitive inhibitor, Allosteric binding, Library design

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Article Details

VOLUME: 6
ISSUE: 6
Year: 2006
Page: [711 - 717]
Pages: 7
DOI: 10.2174/138955706777435698
Price: $65

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