Coagulation and Sepsis

Author(s): F. R. Machado, E. Silva

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 6 , Issue 2 , 2006

Become EABM
Become Reviewer
Call for Editor


Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.

Keywords: Sepsis, coagulation, fibrinolysis, activated protein C, antithrombin, tissue factor

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [175 - 182]
Pages: 8
DOI: 10.2174/187153006777442369
Price: $65

Article Metrics

PDF: 2