Progress in 7-Deazapurine - Pyrrolo[2,3-d]pyrimidine - Ribonucleoside Synthesis

Author(s): Frank Seela, Xiaohua Peng

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 9 , 2006

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This review reports on the synthesis of 7-deazapurine ribonucleosides, including C-nucleosides, 2-C-methyl derivatives and L-enantiomers. It covers the various aspects of convergent nucleoside synthesis such as the Schiff base procedure, the fusion reaction, the metal salt procedures, the Silyl-Hilbert-Johnson reaction, and the nucleobase anion glycosylation. The review discusses the scope and limitations of glycosylation reactions performed on 7-deazapurines. Peracylated ribose derivatives were now employed in the glycosylation, which overcome difficulties reported earlier.

Keywords: 7-deazapurine, pyrrolo[2,3-d]pyrimidine, ribonucleoside, glycosylation, C-nucleoside, L-nucleoside, natural occurrence, pharmacological properties

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Article Details

Year: 2006
Page: [867 - 892]
Pages: 26
DOI: 10.2174/156802606777303649
Price: $65

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